Here we report two cases of coseismic ionospheric disturbances observed through a GPS network in China after the great Wenchuan earthquake at 06:28 UT on 12 May, 2008. One is detected 7.9 min after the earthquake and had an intensive “N” shape oscillated waveform with a pronounced amplitude of about 1 TECU, which propagates approximately southward to the distance about 1000 km with the horizontal phase velocity of 600±84 m/s and the period of 9.5±1.3 min. The other is detected 8.5 min after the earthquake and has an oscillated waveform more like a positive pulse with an amplitude of about 0.5 TECU, which propagates eastward to the distance about 800 km with the horizontal phase velocity of 720±59 m/s and the period of 7.4±0.8 min. These two coseismic ionospheric disturbances are caused by the acoustic gravity waves excited by partial transformation of the acoustic waves originated from the energy release of the earthquake, somewhere near the epicenter. The directional preferences of these two coseismic ionospheric disturbances may be associated with the oblique geomagnetic field lines and the background winds filtering effect.